Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

KRAS GTPases are activated in one-third of cancers and KRAS(G12C) is the most common activating alteration in lung adenocarcinoma(1,2). KRAS(G12C) inhibitors(3,4) are in Phase-I clinical trials and early data show partial responses in ~50% of lung cancer patients. How cancer cells bypass inhibition,...

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Publicado en:Nature
Autores principales: Xue, Jenny Y., Zhao, Yulei, Aronowitz, Jordan, Mai, Trang T., Vides, Alberto, Qeriqi, Besnik, Kim, Dongsung, Li, Chuanchuan, de Stanchina, Elisa, Mazutis, Linas, Risso, Davide, Lito, Piro
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308074/
https://ncbi.nlm.nih.gov/pubmed/31915379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1884-x
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