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Targeting KRAS G12C: from inhibitory mechanism to modulation of antitumor effect in patients
KRAS mutations are among the most common genetic alterations in lung, colorectal and pancreatic cancers. Direct inhibition of KRAS oncoproteins has been a longstanding pursuit in precision oncology, one established shortly after the discovery of RAS mutations in human cancer cells nearly 40 years ag...
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| Published in: | Cell |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7669705/ https://ncbi.nlm.nih.gov/pubmed/33065029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.09.044 |
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