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Targeting KRAS G12C: from inhibitory mechanism to modulation of antitumor effect in patients

KRAS mutations are among the most common genetic alterations in lung, colorectal and pancreatic cancers. Direct inhibition of KRAS oncoproteins has been a longstanding pursuit in precision oncology, one established shortly after the discovery of RAS mutations in human cancer cells nearly 40 years ag...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Kim, Dongsung, Xue, Jenny, Lito, Piro
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669705/
https://ncbi.nlm.nih.gov/pubmed/33065029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.09.044
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