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Targeting KRAS G12C: from inhibitory mechanism to modulation of antitumor effect in patients

KRAS mutations are among the most common genetic alterations in lung, colorectal and pancreatic cancers. Direct inhibition of KRAS oncoproteins has been a longstanding pursuit in precision oncology, one established shortly after the discovery of RAS mutations in human cancer cells nearly 40 years ag...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell
Auteurs principaux: Kim, Dongsung, Xue, Jenny, Lito, Piro
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669705/
https://ncbi.nlm.nih.gov/pubmed/33065029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.09.044
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