Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1

Mitochondrial quality control is mediated by the PTEN-induced kinase 1 (PINK1), a cytoprotective protein that is dysregulated in inflammatory lung injury and neurodegenerative diseases. Here, we show that a ubiquitin E3 ligase receptor component, FBXO7, targets PINK1 for its cellular disposal. FBXO7...

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Udgivet i:JCI Insight
Main Authors: Liu, Yuan, Lear, Travis B., Verma, Manish, Wang, Kent Z.Q., Otero, P. Anthony, McKelvey, Alison C., Dunn, Sarah R., Steer, Erin, Bateman, Nicholas W., Wu, Christine, Jiang, Yu, Weathington, Nathaniel M., Rojas, Mauricio, Chu, Charleen T., Chen, Bill B., Mallampalli, Rama K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308049/
https://ncbi.nlm.nih.gov/pubmed/32493843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131834
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