Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1

Mitochondrial quality control is mediated by the PTEN-induced kinase 1 (PINK1), a cytoprotective protein that is dysregulated in inflammatory lung injury and neurodegenerative diseases. Here, we show that a ubiquitin E3 ligase receptor component, FBXO7, targets PINK1 for its cellular disposal. FBXO7...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Liu, Yuan, Lear, Travis B., Verma, Manish, Wang, Kent Z.Q., Otero, P. Anthony, McKelvey, Alison C., Dunn, Sarah R., Steer, Erin, Bateman, Nicholas W., Wu, Christine, Jiang, Yu, Weathington, Nathaniel M., Rojas, Mauricio, Chu, Charleen T., Chen, Bill B., Mallampalli, Rama K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308049/
https://ncbi.nlm.nih.gov/pubmed/32493843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131834
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