Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization

[Image: see text] The signal transducer and activator of transcription 3 (STAT3) protein is a master regulator of most key hallmarks and enablers of cancer, including cell proliferation and the response to DNA damage. G-Quadruplex (G4) structures are four-stranded noncanonical DNA structures enriche...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Jamroskovic, Jan, Doimo, Mara, Chand, Karam, Obi, Ikenna, Kumar, Rajendra, Brännström, Kristoffer, Hedenström, Mattias, Nath Das, Rabindra, Akhunzianov, Almaz, Deiana, Marco, Kasho, Kazutoshi, Sulis Sato, Sebastian, Pourbozorgi, Parham L., Mason, James E., Medini, Paolo, Öhlund, Daniel, Wanrooij, Sjoerd, Chorell, Erik, Sabouri, Nasim
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307907/
https://ncbi.nlm.nih.gov/pubmed/31990532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b11232
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