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Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21

The chemokines CCL21 and CCL19, through binding of their cognate receptor CCR7, orchestrate lymph node homing of dendritic cells and naïve T cells. CCL21 differs from CCL19 via an unstructured 32 residue C-terminal domain. Previously described roles for the CCL21 C-terminus include GAG-binding, spat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochemistry
Prif Awduron: Moussouras, Natasha A., Hjortø, Gertrud M., Peterson, Francis C., Szpakowska, Martyna, Chevigné, Andy, Rosenkilde, Mette M., Volkman, Brian F., Dwinell, Michael B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307649/
https://ncbi.nlm.nih.gov/pubmed/32182428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00047
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