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Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21
The chemokines CCL21 and CCL19, through binding of their cognate receptor CCR7, orchestrate lymph node homing of dendritic cells and naïve T cells. CCL21 differs from CCL19 via an unstructured 32 residue C-terminal domain. Previously described roles for the CCL21 C-terminus include GAG-binding, spat...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7307649/ https://ncbi.nlm.nih.gov/pubmed/32182428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00047 |
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