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Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase
Most malaria deaths are caused by the protozoan parasite Plasmodium falciparum. Its life cycle is regulated by a cGMP-dependent protein kinase (PfPKG), whose inhibition is a promising antimalaria strategy. Allosteric kinase inhibitors, such as cGMP analogs, offer enhanced selectivity relative to com...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7307193/ https://ncbi.nlm.nih.gov/pubmed/32317283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013070 |
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