Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress

The Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) is a key regulator across the malaria parasite life cycle. Little is known about PfPKG’s activation mechanism. Here we report that the carboxyl cyclic nucleotide binding domain functions as a “gatekeeper” for activation by providing the...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Pathog
Main Authors: Kim, Jeong Joo, Flueck, Christian, Franz, Eugen, Sanabria-Figueroa, Eduardo, Thompson, Eloise, Lorenz, Robin, Bertinetti, Daniela, Baker, David A., Herberg, Friedrich W., Kim, Choel
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412288/
https://ncbi.nlm.nih.gov/pubmed/25646845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004639
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki