Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress

The Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) is a key regulator across the malaria parasite life cycle. Little is known about PfPKG’s activation mechanism. Here we report that the carboxyl cyclic nucleotide binding domain functions as a “gatekeeper” for activation by providing the...

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Udgivet i:PLoS Pathog
Main Authors: Kim, Jeong Joo, Flueck, Christian, Franz, Eugen, Sanabria-Figueroa, Eduardo, Thompson, Eloise, Lorenz, Robin, Bertinetti, Daniela, Baker, David A., Herberg, Friedrich W., Kim, Choel
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412288/
https://ncbi.nlm.nih.gov/pubmed/25646845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004639
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