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RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules

Virus infection leads to activation of the interferon (IFN)-induced endoribonuclease RNase L, which results in degradation of viral and cellular RNAs. Both cellular and viral RNA cleavage products of RNase L bind pattern recognition receptors (PRRs), like retinoic acid-inducible I (Rig-I) and melano...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Manivannan, Praveen, Siddiqui, Mohammad Adnan, Malathi, Krishnamurthy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307175/
https://ncbi.nlm.nih.gov/pubmed/32295917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00205-20
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