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Depletion interactions modulate the binding between disordered proteins in crowded environments

Intrinsically disordered proteins (IDPs) abound in cellular regulation. Their interactions are often transitory and highly sensitive to salt concentration and posttranslational modifications. However, little is known about the effect of macromolecular crowding on the interactions of IDPs with their...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Zosel, Franziska, Soranno, Andrea, Buholzer, Karin J., Nettels, Daniel, Schuler, Benjamin
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306994/
https://ncbi.nlm.nih.gov/pubmed/32487732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921617117
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