A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations

Creatinine is the most common clinical biomarker of renal function. As a substrate for renal transporters, its secretion is susceptible to inhibition by drugs, resulting in transient increase in serum creatinine and false impression of damage to kidney. Novel physiologically based models for creatin...

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Bibliographic Details
Published in:CPT Pharmacometrics Syst Pharmacol
Main Authors: Scotcher, Daniel, Arya, Vikram, Yang, Xinning, Zhao, Ping, Zhang, Lei, Huang, Shiew‐Mei, Rostami‐Hodjegan, Amin, Galetin, Aleksandra
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306622/
https://ncbi.nlm.nih.gov/pubmed/32441889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12509
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