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Conformation-selective analogs of dasatinib reveal insight into kinase inhibitor binding and selectivity
In the kinase field, there are many widely held tenants about conformation-selective inhibitors that have yet to be validated using controlled experiments. We have designed, synthesized, and characterized a series of kinase inhibitor analogs of dasatinib, an FDA-approved kinase inhibitor that binds...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7306399/ https://ncbi.nlm.nih.gov/pubmed/26895387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b01018 |
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