Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design

The regulatory (R) subunit of protein kinase A serves to modulate the activity of protein kinase A in a cAMP-dependent manner and exists in two distinct and structurally dissimilar, end point cAMP-bound “B” and C-subunit-bound “H”-conformations. Here we report mechanistic details of cAMP action as y...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Badireddy, Suguna, Yunfeng, Gao, Ritchie, Mark, Akamine, Pearl, Wu, Jian, Kim, Choel W., Taylor, Susan S., Qingsong, Lin, Swaminathan, Kunchithapadam, Anand, Ganesh S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047156/
https://ncbi.nlm.nih.gov/pubmed/21081668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M110.004390
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados