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Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors
Metabotropic glutamate receptors (mGluRs) are G protein coupled receptors that play important roles in synaptic plasticity and other neuro-physiological and pathological processes. Allosteric mGluR ligands are particularly promising drug targets because of their modulatory effects – enhancing or sup...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2259417/ https://ncbi.nlm.nih.gov/pubmed/18315847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-9-S1-S16 |
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