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Enhancement of dissolution of atorvastatin through preparation of polymeric solid dispersions using supercritical fluid technology
BACKGROUND AND PURPOSE: This study aimed at preparation of solid dispersions in order to enhance dissolution of poorly water-soluble atorvastatin using supercritical CO2 technology. Atorvastatin has poor bioavailability of 12%, mainly due to poor water solubility and dissolution. Dispersion of drugs...
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| Publicado no: | Res Pharm Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wolters Kluwer - Medknow
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7306245/ https://ncbi.nlm.nih.gov/pubmed/32582352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1735-5362.283812 |
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