Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01

T cells isolated from the pancreatic infiltrates of nonobese diabetic mice have been shown to recognize epitopes formed by the covalent cross-linking of proinsulin and secretory granule peptides. Formation of such hybrid insulin peptides (HIPs) was confirmed through mass spectrometry, and responses...

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Veröffentlicht in:Diabetes
Hauptverfasser: Arribas-Layton, David, Guyer, Perrin, Delong, Thomas, Dang, Mylinh, Chow, I-Ting, Speake, Cate, Greenbaum, Carla J., Kwok, William W., Baker, Rocky L., Haskins, Kathryn, James, Eddie A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2020
Schlagworte:
Immunology and Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306133/
https://ncbi.nlm.nih.gov/pubmed/32291282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0620
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