Caspase-8-dependent inflammatory responses are controlled by its adapter, FADD, and necroptosis

Cell death pathways regulate various homeostatic processes. Autoimmune lymphoproliferative syndrome (ALPS) in humans and Lymphoproliferative (LPR) disease in mice are a result of abrogated CD95-induced apoptosis. Because Caspase-8 mediates CD95 signaling, we applied genetic approaches to dissect the...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Tummers, Bart, Mari, Luigi, Guy, Clifford S., Heckmann, Bradlee L., Rodriguez, Diego A., Rühl, Sebastian, Moretti, Julien, Crawford, Jeremy Chase, Fitzgerald, Patrick, Kanneganti, Thirumala-Devi, Janke, Laura J., Pelletier, Stephane, Blander, J. Magarian, Green, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306001/
https://ncbi.nlm.nih.gov/pubmed/32428502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.04.010
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