Caspase-8-dependent inflammatory responses are controlled by its adapter, FADD, and necroptosis

Cell death pathways regulate various homeostatic processes. Autoimmune lymphoproliferative syndrome (ALPS) in humans and Lymphoproliferative (LPR) disease in mice are a result of abrogated CD95-induced apoptosis. Because Caspase-8 mediates CD95 signaling, we applied genetic approaches to dissect the...

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Publicado en:Immunity
Autores principales: Tummers, Bart, Mari, Luigi, Guy, Clifford S., Heckmann, Bradlee L., Rodriguez, Diego A., Rühl, Sebastian, Moretti, Julien, Crawford, Jeremy Chase, Fitzgerald, Patrick, Kanneganti, Thirumala-Devi, Janke, Laura J., Pelletier, Stephane, Blander, J. Magarian, Green, Douglas R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306001/
https://ncbi.nlm.nih.gov/pubmed/32428502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.04.010
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