Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T-cell Acute Lymphoblastic Leukemia

The identification of SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase) as a target for modulating gain-of-function NOTCH1 mutations in Notch-dependent cancers has spurred the development of this compound class for cancer therapeutics. Despite the innate toxicity challenge associated with SERCA inh...

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Publicado no:Cell Chem Biol
Main Authors: Marchesini, Matteo, Gherli, Andrea, Montanaro, Anna, Patrizi, Laura, Sorrentino, Claudia, Pagliaro, Luca, Rompietti, Chiara, Kitara, Samuel, Heit, Sabine, Olesen, Claus E., Møller, Jesper V., Savi, Monia, Bocchi, Leonardo, Vilella, Rocchina, Rizzi, Federica, Baglione, Marilena, Rastelli, Giorgia, Loiacono, Caterina, Starza, Roberta La, Mecucci, Cristina, Stegmaier, Kimberly, Aversa, Franco, Stilli, Donatella, Winther, Anne-Marie Lund, Sportoletti, Paolo, Bublitz, Maike, Dalby-Brown, William, Roti, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305996/
https://ncbi.nlm.nih.gov/pubmed/32386594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.04.002
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