Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T-cell Acute Lymphoblastic Leukemia

The identification of SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase) as a target for modulating gain-of-function NOTCH1 mutations in Notch-dependent cancers has spurred the development of this compound class for cancer therapeutics. Despite the innate toxicity challenge associated with SERCA inh...

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Xehetasun bibliografikoak
Argitaratua izan da:Cell Chem Biol
Egile Nagusiak: Marchesini, Matteo, Gherli, Andrea, Montanaro, Anna, Patrizi, Laura, Sorrentino, Claudia, Pagliaro, Luca, Rompietti, Chiara, Kitara, Samuel, Heit, Sabine, Olesen, Claus E., Møller, Jesper V., Savi, Monia, Bocchi, Leonardo, Vilella, Rocchina, Rizzi, Federica, Baglione, Marilena, Rastelli, Giorgia, Loiacono, Caterina, Starza, Roberta La, Mecucci, Cristina, Stegmaier, Kimberly, Aversa, Franco, Stilli, Donatella, Winther, Anne-Marie Lund, Sportoletti, Paolo, Bublitz, Maike, Dalby-Brown, William, Roti, Giovanni
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305996/
https://ncbi.nlm.nih.gov/pubmed/32386594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.04.002
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