Generation of knockout rabbits with X-linked severe combined immunodeficiency (X-SCID) using CRISPR/Cas9

Severe immunodeficient mice are widely used to examine human and animal cells behaviour in vivo. However, mice are short-lived and small in size; while large animals require specific large-scale equipment. Rabbits are also commonly employed as experimental models and are larger than mice or rats, ea...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hashikawa, Yoshiko, Hayashi, Ryuhei, Tajima, Masaru, Okubo, Toru, Azuma, Shohei, Kuwamura, Mitsuru, Takai, Naofumi, Osada, Yasuyuki, Kunihiro, Yayoi, Mashimo, Tomoji, Nishida, Kohji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305219/
https://ncbi.nlm.nih.gov/pubmed/32561775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66780-6
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