Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition

Phosphorylation of intrinsically disordered eIF4E binding proteins (4E-BPs) regulates cap-dependent translation by weakening their ability to compete with eIF4G for eIF4E binding within the translation initiation complex. We previously showed that phosphorylation of T37 and T46 in 4E-BP2 induces fol...

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Publicat a:Nat Commun
Autors principals: Dawson, Jennifer E., Bah, Alaji, Zhang, Zhenfu, Vernon, Robert M., Lin, Hong, Chong, P. Andrew, Vanama, Manasvi, Sonenberg, Nahum, Gradinaru, Claudiu C., Forman-Kay, Julie D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305185/
https://ncbi.nlm.nih.gov/pubmed/32561718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16783-8
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