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Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP
eIF4E, the mRNA 5′ cap-binding protein, is regulated by its binding protein (4E-BP), a downstream target of phosphatidylinositol-3-OH kinase [PI(3)K] signaling. We show that Drosophila 4E-BP (d4E-BP) activity becomes critical for survival under dietary restriction and oxidative stress, and is linked...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1186182/ https://ncbi.nlm.nih.gov/pubmed/16055649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1311805 |
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