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Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP

eIF4E, the mRNA 5′ cap-binding protein, is regulated by its binding protein (4E-BP), a downstream target of phosphatidylinositol-3-OH kinase [PI(3)K] signaling. We show that Drosophila 4E-BP (d4E-BP) activity becomes critical for survival under dietary restriction and oxidative stress, and is linked...

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Bibliografski detalji
Glavni autori: Tettweiler, Gritta, Miron, Mathieu, Jenkins, Mark, Sonenberg, Nahum, Lasko, Paul F.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1186182/
https://ncbi.nlm.nih.gov/pubmed/16055649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1311805
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