Human TRA2A determines influenza A virus host adaptation by regulating viral mRNA splicing

Several avian influenza A viruses (IAVs) have adapted to mammalian species, including humans. To date, the mechanisms enabling these host shifts remain incompletely understood. Here, we show that a host factor, human TRA2A (huTRA2A), inhibits avian IAV replication, but benefits human IAV replication...

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Библиографические подробности
Опубликовано в: :Sci Adv
Главные авторы: Zhu, Yinxing, Wang, Ruifang, Yu, Luyao, Sun, Huimin, Tian, Shan, Li, Peng, Jin, Meilin, Chen, Huanchun, Ma, Wenjun, Zhou, Hongbo
Формат: Artigo
Язык:Inglês
Опубликовано: American Association for the Advancement of Science 2020
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304988/
https://ncbi.nlm.nih.gov/pubmed/32596447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz5764
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