Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation

[Image: see text] The ability to create ways to control drug activation at specific tissues while sparing healthy tissues remains a major challenge. The administration of exogenous target-specific triggers offers the potential for traceless release of active drugs on tumor sites from antibody–drug c...

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Pubblicato in:J Am Chem Soc
Autori principali: Oliveira, Bruno L., Stenton, Benjamin J., Unnikrishnan, V. B., de Almeida, Cátia Rebelo, Conde, João, Negrão, Magda, Schneider, Felipe S. S., Cordeiro, Carlos, Ferreira, Miguel Godinho, Caramori, Giovanni F., Domingos, Josiel B., Fior, Rita, Bernardes, Gonçalo J. L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304066/
https://ncbi.nlm.nih.gov/pubmed/32456416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c01622
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