The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

Cancer/testis (CT) antigens are proteins whose expression is normally restricted to germ cells yet aberrantly activated in tumors, where their functions remain relatively cryptic. Here we report that ZNF165, a CT antigen frequently expressed in triple-negative breast cancer (TNBC), associates with S...

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Vydáno v:eLife
Hlavní autoři: Gibbs, Zane A, Reza, Luis C, Cheng, Chun-Chun, Westcott, Jill M, McGlynn, Kathleen, Whitehurst, Angelique W
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7302877/
https://ncbi.nlm.nih.gov/pubmed/32515734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57679
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