Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells in a cell line model

BACKGROUND: CDK4/6 inhibitors such as ribociclib are becoming widely used targeted therapies in hormone-receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2−) breast cancer. However, cancers can advance due to drug resistance, a problem in which tumor heterogeneity and evo...

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Udgivet i:Cancer Cell Int
Main Authors: Grolmusz, Vince Kornél, Chen, Jinfeng, Emond, Rena, Cosgrove, Patrick A., Pflieger, Lance, Nath, Aritro, Moos, Philip J., Bild, Andrea H.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301982/
https://ncbi.nlm.nih.gov/pubmed/32565737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-020-01337-1
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