Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation

BACKGROUND: Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms. METHODS AND RESULTS: AngI infusion led to thoracic and abdominal aortic aneurysm...

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Published in:Circ J
Main Authors: Sawada, Hisashi, Kukida, Masayoshi, Chen, Xiaofeng, Howatt, Deborah A., Moorleghen, Jessica J., Balakrishnan, Anju, Wu, Congqing, Daugherty, Alan, Lu, Hong S.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301959/
https://ncbi.nlm.nih.gov/pubmed/32238693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1253/circj.CJ-19-0955
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