Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay

The COVID-19 pandemic, caused by SARS-CoV-2, is a pressing public health emergency garnering rapid response from scientists across the globe. Host cell invasion is initiated through direct binding of the viral spike protein to the host receptor angiotensin-converting enzyme 2 (ACE2). Disrupting the...

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Bibliografske podrobnosti
izdano v:bioRxiv
Main Authors: Hanson, Quinlin M., Wilson, Kelli M., Shen, Min, Itkin, Zina, Eastman, Richard T., Shinn, Paul, Hall, Matthew D.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301901/
https://ncbi.nlm.nih.gov/pubmed/32577632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.16.154708
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