Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay

The neurodegenerative Huntington’s disease (HD) is caused by a polyglutamine (polyQ) amplification in the huntingtin protein (HTT). Currently there is no effective therapy available for HD; however, several efforts are directed to develop and optimize HTT-lowering methods to improve HD phenotypes. T...

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Veröffentlicht in:eNeuro
Hauptverfasser: Baldo, Barbara, Sajjad, Muhammad Umar, Cheong, Rachel Y., Bigarreau, Julie, Vijayvargia, Ravi, McLean, Catriona, Perrier, Anselme L., Seong, Ihn Sik, Halliday, Glenda, Petersén, Åsa, Kirik, Deniz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2018
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Methods/New Tools
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179573/
https://ncbi.nlm.nih.gov/pubmed/30310861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0234-18.2018
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