Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins

The deleterious effects of aging on the brain remain to be fully elucidated. In the present study, proteomic changes of young (4-month) and aged (16-month) B6129SF2/J male mouse hippocampus and cerebral cortex were investigated by using nano liquid chromatography tandem mass spectrometry (NanoLC-ESI...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Li, Yingchao, Yu, Haitao, Chen, Chongyang, Li, Shupeng, Zhang, Zaijun, Xu, Hua, Zhu, Feiqi, Liu, Jianjun, Spencer, Peter S., Dai, Zhongliang, Yang, Xifei
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301248/
https://ncbi.nlm.nih.gov/pubmed/32587661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5408452
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