Mitochondrial Molecular Abnormalities Revealed by Proteomic Analysis of Hippocampal Organelles of Mice Triple Transgenic for Alzheimer Disease

Mitochondrial dysfunction is implicated in the pathogenesis of Alzheimer’s disease (AD). However, the precise mitochondrial molecular deficits in AD remain poorly understood. Mitochondrial and nuclear proteomic analysis in mature male triple transgenic AD mice (PS1M146V/APPSwe/TauP301L) by two-dimen...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Yu, Haitao, Lin, Xuemei, Wang, Dian, Zhang, Zaijun, Guo, Yi, Ren, Xiaohu, Xu, Benhong, Yuan, Jianhui, Liu, Jianjun, Spencer, Peter S., Wang, Jian-Zhi, Yang, Xifei
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854685/
https://ncbi.nlm.nih.gov/pubmed/29593495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00074
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