Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction: A Randomized Clinical Trial

IMPORTANCE: Severe early onset fetal growth restriction caused by placental dysfunction leads to high rates of perinatal mortality and neonatal morbidity. The phosphodiesterase 5 inhibitor, sildenafil, inhibits cyclic guanosine monophosphate hydrolysis, thereby activating the effects of nitric oxide...

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Bibliografiske detaljer
Udgivet i:JAMA Netw Open
Main Authors: Pels, Anouk, Derks, Jan, Elvan-Taspinar, Ayten, van Drongelen, Joris, de Boer, Marjon, Duvekot, Hans, van Laar, Judith, van Eyck, Jim, Al-Nasiry, Salwan, Sueters, Marieke, Post, Marinka, Onland, Wes, van Wassenaer-Leemhuis, Aleid, Naaktgeboren, Christiana, Jakobsen, Janus C., Gluud, Christian, Duijnhoven, Ruben G., Lely, Titia, Gordijn, Sanne, Ganzevoort, Wessel
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Association 2020
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301225/
https://ncbi.nlm.nih.gov/pubmed/32585017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2020.5323
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