Liver-Specific siRNA-Mediated Stat3 or C3 Knockdown Improves the Outcome of Experimental Autoimmune Myocarditis

Myocarditis can lead to autoimmune disease, dilated cardiomyopathy, and heart failure, which is modeled in the mouse by cardiac myosin immunization (experimental autoimmune myocarditis [EAM]). Signal transducer and activator of transcription 3 (STAT3) systemic inhibition exerts both preventive and t...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Avalle, Lidia, Marino, Francesca, Camporeale, Annalisa, Guglielmi, Chiara, Viavattene, Daniele, Bandini, Silvio, Conti, Laura, Cimino, James, Forni, Marco, Zanini, Cristina, Ghigo, Alessandra, Bogorad, Roman L., Cavallo, Federica, Provero, Paolo, Koteliansky, Victor, Poli, Valeria
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301178/
https://ncbi.nlm.nih.gov/pubmed/32577433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.05.023
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