Development of a DNA double-strand break-free base editing tool in Corynebacterium glutamicum for genome editing and metabolic engineering

As a traditional amino acid producing bacterium, Corynebacterium glutamicum is a platform strain for production of various fine chemicals. Based on the CRISPR (Clustered regularly interspaced short palindromic repeats)-Cas9 system, gene editing tools that enable base conversion in the genome of C. g...

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Bibliographic Details
Published in:Metab Eng Commun
Main Authors: Deng, Chen, Lv, Xueqin, Li, Jianghua, Liu, Yanfeng, Du, Guocheng, Liu, Long
Format: Artigo
Language:Inglês
Published: Elsevier 2020
Subjects:
Special issue on Model chassis cells edited by Long Liu and Rodrigo Ledesma- Amaro
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7300154/
https://ncbi.nlm.nih.gov/pubmed/32577397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mec.2020.e00135
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