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PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy
Phosphatase and tensin homolog (PTEN) regulates synaptic density in development; however, whether PTEN also regulates synapse loss in a neurodegenerative disorder such as frontotemporal lobar degeneration with Tau deposition (FTLD-Tau) has not been explored. Here, we found that pathological Tau prom...
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| Veröffentlicht in: | Acta Neuropathol |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Berlin Heidelberg
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7300099/ https://ncbi.nlm.nih.gov/pubmed/32236736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02151-9 |
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