PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy

Phosphatase and tensin homolog (PTEN) regulates synaptic density in development; however, whether PTEN also regulates synapse loss in a neurodegenerative disorder such as frontotemporal lobar degeneration with Tau deposition (FTLD-Tau) has not been explored. Here, we found that pathological Tau prom...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Acta Neuropathol
Main Authors: Benetatos, Joseph, Bennett, Rachel E., Evans, Harrison T., Ellis, Sevannah A., Hyman, Bradley T., Bodea, Liviu-Gabriel, Götz, Jürgen
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2020
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7300099/
https://ncbi.nlm.nih.gov/pubmed/32236736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02151-9
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