Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice

Cerebral cavernous malformations (CCMs) are vascular lesions predominantly developing in the central nervous system (CNS), with no effective treatments other than surgery. Loss-of-function mutation in CCM1/krev interaction trapped 1 (KRIT1), CCM2, or CCM3/programmed cell death 10 (PDCD10) causes les...

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Udgivet i:PLoS Biol
Main Authors: Li, Jia, Zhao, Yang, Choi, Jaesung, Ting, Ka Ka, Coleman, Paul, Chen, Jinbiao, Cogger, Victoria C., Wan, Li, Shi, Zhongsong, Moller, Thorleif, Zheng, Xiangjian, Vadas, Mathew A., Gamble, Jennifer R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299406/
https://ncbi.nlm.nih.gov/pubmed/32502201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000734
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