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Identification of functionally connected multi-omic biomarkers for Alzheimer’s disease using modularity-constrained Lasso

Large-scale genome wide association studies (GWASs) have led to discovery of many genetic risk factors in Alzheimer’s disease (AD), such as APOE, TOMM40 and CLU. Despite the significant progress, it remains a major challenge to functionally validate these genetic findings and translate them into tar...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Xie, Linhui, Varathan, Pradeep, Nho, Kwangsik, Saykin, Andrew J., Salama, Paul, Yan, Jingwen
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299377/
https://ncbi.nlm.nih.gov/pubmed/32555747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0234748
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