Identification of functionally connected multi-omic biomarkers for Alzheimer’s disease using modularity-constrained Lasso

Large-scale genome wide association studies (GWASs) have led to discovery of many genetic risk factors in Alzheimer’s disease (AD), such as APOE, TOMM40 and CLU. Despite the significant progress, it remains a major challenge to functionally validate these genetic findings and translate them into tar...

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Udgivet i:PLoS One
Main Authors: Xie, Linhui, Varathan, Pradeep, Nho, Kwangsik, Saykin, Andrew J., Salama, Paul, Yan, Jingwen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299377/
https://ncbi.nlm.nih.gov/pubmed/32555747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0234748
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