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Identification of functionally connected multi-omic biomarkers for Alzheimer’s disease using modularity-constrained Lasso

Large-scale genome wide association studies (GWASs) have led to discovery of many genetic risk factors in Alzheimer’s disease (AD), such as APOE, TOMM40 and CLU. Despite the significant progress, it remains a major challenge to functionally validate these genetic findings and translate them into tar...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Xie, Linhui, Varathan, Pradeep, Nho, Kwangsik, Saykin, Andrew J., Salama, Paul, Yan, Jingwen
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299377/
https://ncbi.nlm.nih.gov/pubmed/32555747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0234748
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