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Ankyrin-G mediates targeting of both Na(+) and K(ATP) channels to the rat cardiac intercalated disc
We investigated targeting mechanisms of Na(+) and K(ATP) channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density. Mutagenesis of the Kir6.2 ankyrin binding site disrupts this functional coupl...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7299345/ https://ncbi.nlm.nih.gov/pubmed/31934859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52373 |
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