Ankyrin-G mediates targeting of both Na(+) and K(ATP) channels to the rat cardiac intercalated disc

We investigated targeting mechanisms of Na(+) and K(ATP) channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density. Mutagenesis of the Kir6.2 ankyrin binding site disrupts this functional coupl...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:eLife
Hlavní autoři: Yang, Hua-Qian, Pérez-Hernández, Marta, Sanchez-Alonso, Jose, Shevchuk, Andriy, Gorelik, Julia, Rothenberg, Eli, Delmar, Mario, Coetzee, William A
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Human Biology and Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299345/
https://ncbi.nlm.nih.gov/pubmed/31934859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52373
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky