Ankyrin-G mediates targeting of both Na(+) and K(ATP) channels to the rat cardiac intercalated disc

We investigated targeting mechanisms of Na(+) and K(ATP) channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density. Mutagenesis of the Kir6.2 ankyrin binding site disrupts this functional coupl...

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Pubblicato in:eLife
Autori principali: Yang, Hua-Qian, Pérez-Hernández, Marta, Sanchez-Alonso, Jose, Shevchuk, Andriy, Gorelik, Julia, Rothenberg, Eli, Delmar, Mario, Coetzee, William A
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Human Biology and Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299345/
https://ncbi.nlm.nih.gov/pubmed/31934859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52373
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