CRISPR-Cas13 inhibitors block RNA-editing in bacteria and mammalian cells

Cas13 has demonstrated unique and broad utility in RNA editing, nucleic acid detection, and disease diagnosis; however, a constantly active Cas enzyme may induce unwanted effects. Bacteriophage- or prophage regions-encoded anti-CRISPR (acr) molecules provide the potential to control targeting specif...

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Publicado en:Mol Cell
Autores principales: Lin, Ping, Qin, Shugang, Pu, Qinqin, Wang, Zhihan, Wu, Qun, Gao, Pan, Schettler, Jacob, Guo, Kai, Li, Rongpeng, Li, Guoping, Huang, Canhua, Wei, Yuquan, Gao, George Fu, Jiang, Jianxin, Wu, Min
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299153/
https://ncbi.nlm.nih.gov/pubmed/32348779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.03.033
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