High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination

Discovery of CRISPR-Cas systems is one of paramount importance in the field of microbiology. Currently, how CRISPR-Cas systems are finely regulated remains to be defined. Here we use small regulatory RNA (sRNA) library to screen sRNAs targeting type I-F CRISPR-Cas system through proximity ligation b...

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Pubblicato in:Nat Commun
Autori principali: Lin, Ping, Pu, Qinqin, Wu, Qun, Zhou, Chuanmin, Wang, Biao, Schettler, Jacob, Wang, Zhihan, Qin, Shugang, Gao, Pan, Li, Rongpeng, Li, Guoping, Cheng, Zhenyu, Lan, Lefu, Jiang, Jianxin, Wu, Min
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700203/
https://ncbi.nlm.nih.gov/pubmed/31427601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11695-8
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