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Solid-Phase Synthesis of DNA-Encoded Libraries Via An “Aldehyde Explosion” Strategy
We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves “exploding” an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.
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| Udgivet i: | Chem Commun (Camb) |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7298663/ https://ncbi.nlm.nih.gov/pubmed/32215395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc01474e |
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