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Solid-Phase Synthesis of DNA-Encoded Libraries Via An “Aldehyde Explosion” Strategy

We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves “exploding” an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Chem Commun (Camb)
Egile Nagusiak: Paciaroni, Nicholas G., Ndungu, John M., Kodadek, Thomas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298663/
https://ncbi.nlm.nih.gov/pubmed/32215395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc01474e
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