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RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells

During angiogenesis, VEGF acts as an attractive cue for endothelial cells (ECs), while Sema3E mediates repulsive cues. Here, we show that the small GTPase RhoJ integrates these opposing signals in directional EC migration. In the GTP‐bound state, RhoJ interacts with the cytoplasmic domain of PlexinD...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:EMBO J
Päätekijät: Fukushima, Yoko, Nishiyama, Koichi, Kataoka, Hiroshi, Fruttiger, Marcus, Fukuhara, Shigetomo, Nishida, Kohji, Mochizuki, Naoki, Kurihara, Hiroki, Nishikawa, Shin‐Ichi, Uemura, Akiyoshi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298304/
https://ncbi.nlm.nih.gov/pubmed/32347571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102930
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