RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells

During angiogenesis, VEGF acts as an attractive cue for endothelial cells (ECs), while Sema3E mediates repulsive cues. Here, we show that the small GTPase RhoJ integrates these opposing signals in directional EC migration. In the GTP‐bound state, RhoJ interacts with the cytoplasmic domain of PlexinD...

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Publicado en:EMBO J
Autores principales: Fukushima, Yoko, Nishiyama, Koichi, Kataoka, Hiroshi, Fruttiger, Marcus, Fukuhara, Shigetomo, Nishida, Kohji, Mochizuki, Naoki, Kurihara, Hiroki, Nishikawa, Shin‐Ichi, Uemura, Akiyoshi
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298304/
https://ncbi.nlm.nih.gov/pubmed/32347571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102930
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